Mosquito receptor for human-sweat odorant

Elissa A. Hallem, A. Nicole Fox, Laurence J. Zwiebel and John R. Carlson ()
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Elissa A. Hallem: Cellular and Developmental Biology, Yale University
A. Nicole Fox: Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University
Laurence J. Zwiebel: Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University
John R. Carlson: Cellular and Developmental Biology, Yale University

Nature, 2004, vol. 427, issue 6971, 212-213

Abstract: Abstract Female Anopheles mosquitoes, the world's most important vector of Plasmodium falciparum malaria, locate their human hosts primarily through olfactory cues1, but the molecular mechanisms that underlie this recognition are a mystery. Here we show that the Anopheles gambiae protein AgOr1, a female-specific member of a family of putative odorant receptors2,3, responds to a component of human sweat. Compounds designed to activate or block receptors of this type could function as attractants for trapping mosquitoes or as insect repellents in helping to control Anopheles and other insect pests.

Date: 2004
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DOI: 10.1038/427212a

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