Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

Nader Sanai (), Anthony D. Tramontin, Alfredo Quiñones-Hinojosa, Nicholas M. Barbaro, Nalin Gupta, Sandeep Kunwar, Michael T. Lawton, Michael W. McDermott, Andrew T. Parsa, José Manuel-García Verdugo, Mitchel S. Berger and Arturo Alvarez-Buylla ()
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Nader Sanai: Department of Neurological Surgery and Brain Tumor Research Center
Anthony D. Tramontin: Department of Neurological Surgery and Brain Tumor Research Center
Alfredo Quiñones-Hinojosa: Department of Neurological Surgery and Brain Tumor Research Center
Nicholas M. Barbaro: Department of Neurological Surgery and Brain Tumor Research Center
Nalin Gupta: Department of Neurological Surgery and Brain Tumor Research Center
Sandeep Kunwar: Department of Neurological Surgery and Brain Tumor Research Center
Michael T. Lawton: Department of Neurological Surgery and Brain Tumor Research Center
Michael W. McDermott: Department of Neurological Surgery and Brain Tumor Research Center
Andrew T. Parsa: Department of Neurological Surgery and Brain Tumor Research Center
José Manuel-García Verdugo: University of Valencia
Mitchel S. Berger: Department of Neurological Surgery and Brain Tumor Research Center
Arturo Alvarez-Buylla: Department of Neurological Surgery and Brain Tumor Research Center

Nature, 2004, vol. 427, issue 6976, 740-744

Abstract: Abstract The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain, generating thousands of olfactory bulb neurons every day1. If the adult human brain contains a comparable germinal region, this could have considerable implications for future neuroregenerative therapy. Stem cells have been isolated from the human brain2,3,4,5,6,7, but the identity, organization and function of adult neural stem cells in the human SVZ are unknown. Here we describe a ribbon of SVZ astrocytes lining the lateral ventricles of the adult human brain that proliferate in vivo and behave as multipotent progenitor cells in vitro. This astrocytic ribbon has not been observed in other vertebrates studied. Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain.

Date: 2004
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DOI: 10.1038/nature02301

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