microRNA-mediated repression of rolled leaf1 specifies maize leaf polarity

Michelle T. Juarez, Jonathan S. Kui, Julie Thomas, Bradley A. Heller and Marja C. P. Timmermans ()
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Michelle T. Juarez: Cold Spring Harbor Laboratory
Jonathan S. Kui: Cold Spring Harbor Laboratory
Julie Thomas: Cold Spring Harbor Laboratory
Bradley A. Heller: Cold Spring Harbor Laboratory
Marja C. P. Timmermans: Cold Spring Harbor Laboratory

Nature, 2004, vol. 428, issue 6978, 84-88

Abstract: Abstract In both animals and plants, many developmentally important regulatory genes have complementary microRNAs (miRNAs), which suggests that these miRNAs constitute a class of developmental signalling molecules1. Leaves of higher plants exhibit a varying degree of asymmetry along the adaxial/abaxial (upper/lower) axis. This asymmetry is specified through the polarized expression of class III homeodomain/leucine zipper (HD-ZIPIII) genes2,3,4. In Arabidopsis, three such genes, PHABULOSA (PHB), PHAVOLUTA (PHV) and REVOLUTA (REV), are expressed throughout the incipient leaf, but become adaxially localized after primordium emergence. Downregulation of the HD-ZIPIII genes allows expression of the KANADI and YABBY genes, which specify abaxial fate5,6,7,8. PHB, PHV and REV transcripts contain a complementary site for miRNA165 and miRNA166, which can direct their cleavage in vitro9,10,11. Here we show that miRNA166 constitutes a highly conserved polarizing signal whose expression pattern spatially defines the expression domain of the maize hd-zipIII family member rolled leaf1 (rld1). Moreover, the progressively expanding expression pattern of miRNA166 during leaf development and its accumulation in phloem suggests that miRNA166 may form a movable signal that emanates from a signalling centre below the incipient leaf.

Date: 2004
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DOI: 10.1038/nature02363

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