Mice cloned from olfactory sensory neurons

Kevin Eggan, Kristin Baldwin, Michael Tackett, Joseph Osborne, Joseph Gogos, Andrew Chess (), Richard Axel and Rudolf Jaenisch ()
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Kevin Eggan: Massachusetts Institute of Technology
Kristin Baldwin: Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University
Michael Tackett: Massachusetts Institute of Technology
Joseph Osborne: Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University
Joseph Gogos: Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University
Andrew Chess: Massachusetts Institute of Technology
Richard Axel: Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University
Rudolf Jaenisch: Massachusetts Institute of Technology

Nature, 2004, vol. 428, issue 6978, 44-49

Abstract: Abstract Cloning by nuclear transplantation has been successfully carried out in various mammals, including mice. Until now mice have not been cloned from post-mitotic cells such as neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of odorant receptor gene expression and the organization of odorant receptor genes in cloned mice was indistinguishable from wild-type animals, indicating that irreversible changes to the DNA of olfactory neurons do not accompany receptor gene choice.

Date: 2004
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DOI: 10.1038/nature02375

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