Creation of long-lasting blood vessels

Naoto Koike, Dai Fukumura, Oliver Gralla, Patrick Au, Jeffrey S. Schechner and Rakesh K. Jain ()
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Naoto Koike: Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
Dai Fukumura: Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
Oliver Gralla: Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
Patrick Au: Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
Jeffrey S. Schechner: Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
Rakesh K. Jain: Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School

Nature, 2004, vol. 428, issue 6979, 138-139

Abstract: Abstract The construction of stable blood vessels is a fundamental challenge for tissue engineering in regenerative medicine. Although certain genes can be introduced into vascular cells to enhance their survival and proliferation, these manipulations may be oncogenic. We show here that a network of long-lasting blood vessels can be formed in mice by co-implantation of vascular endothelial cells and mesenchymal precursor cells, by-passing the need for risky genetic manipulations. These networks are stable and functional for one year in vivo.

Date: 2004
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DOI: 10.1038/428138a

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