Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Masamichi Yamamoto, Yukio Saijoh, Aitana Perea-Gomez, William Shawlot, Richard R. Behringer, Siew-Lan Ang, Hiroshi Hamada () and Chikara Meno
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Masamichi Yamamoto: Osaka University, and CREST, Japan Science and Technology Corporation (JST)
Yukio Saijoh: Osaka University, and CREST, Japan Science and Technology Corporation (JST)
Aitana Perea-Gomez: IGBMC/CNRS/INSERM, Université Louis Pasteur
William Shawlot: University of Texas
Richard R. Behringer: University of Texas
Siew-Lan Ang: IGBMC/CNRS/INSERM, Université Louis Pasteur
Hiroshi Hamada: Osaka University, and CREST, Japan Science and Technology Corporation (JST)
Chikara Meno: Osaka University, and CREST, Japan Science and Technology Corporation (JST)

Nature, 2004, vol. 428, issue 6981, 387-392

Abstract: Abstract Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.

Date: 2004
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DOI: 10.1038/nature02418

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