A marker for Stevens–Johnson syndrome

Wen-Hung Chung, Shuen-Iu Hung, Hong-Shang Hong, Mo-Song Hsih, Li-Cheng Yang, Hsin-Chun Ho, Jer-Yuarn Wu and Yuan-Tsong Chen ()
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Wen-Hung Chung: Chang Gung Memorial Hospital
Shuen-Iu Hung: Institute of Biomedical Sciences, Academia Sinica
Hong-Shang Hong: Chang Gung Memorial Hospital
Mo-Song Hsih: Chang Gung Memorial Hospital
Li-Cheng Yang: Chang Gung Memorial Hospital
Hsin-Chun Ho: Chang Gung Memorial Hospital
Jer-Yuarn Wu: Institute of Biomedical Sciences, Academia Sinica
Yuan-Tsong Chen: Institute of Biomedical Sciences, Academia Sinica

Nature, 2004, vol. 428, issue 6982, 486-486

Abstract: Abstract Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication1,2,3. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA–B*1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens–Johnson syndrome.

Date: 2004
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DOI: 10.1038/428486a

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