The DNA sequence and analysis of human chromosome 13

Dunham, A.; Matthews, L. H.; Burton, J.; Ashurst, J. L.; Howe, K. L.; Ashcroft, K. J.; Beare, D. M.; Burford, D. C.; Hunt, S. E.; Griffiths-Jones, S.; Jones, M. C.; Keenan, S. J.; Oliver, K.; Scott, C. E.; Ainscough, R.; Almeida, J. P.; Ambrose, K. D.; Andrews, D. T.; Ashwell, R. I. S.; Babbage, A. K.; Bagguley, C. L.; Bailey, J.; Bannerjee, R.; Barlow, K. F.; Bates, K.; Beasley, H.; Bird, C. P.; Bray-Allen, S.; Brown, A. J.; Brown, J. Y.; Burrill, W.; Carder, C.; Carter, N. P.; Chapman, J. C.; Clamp, M. E.; Clark, S. Y.; Clarke, G.; Clee, C. M.; Clegg, S. C. M.; Cobley, V.; Collins, J. E.; Corby, N.; Coville, G. J.; Deloukas, P.; Dhami, P.; Dunham, I.; Dunn, M.; Earthrowl, M. E.; Ellington, A. G.; Faulkner, L.; Frankish, A. G.; Frankland, J.; French, L.; Garner, P.; Garnett, J.; Gilbert, J. G. R.; Gilson, C. J.; Ghori, J.; Grafham, D. V.; Gribble, S. M.; Griffiths, C.; Hall, R. E.; Hammond, S.; Harley, J. L.; Hart, E. A.; Heath, P. D.; Howden, P. J.; Huckle, E. J.; Hunt, P. J.; Hunt, A. R.; Johnson, C.; Johnson, D.; Kay, M.; Kimberley, A. M.; King, A.; Laird, G. K.; Langford, C. J.; Lawlor, S.; Leongamornlert, D. A.; Lloyd, D. M.; Lloyd, C.; Loveland, J. E.; Lovell, J.; Martin, S.; Mashreghi-Mohammadi, M.; McLaren, S. J.; McMurray, A.; Milne, S.; Moore, M. J. F.; Nickerson, T.; Palmer, S. A.; Pearce, A. V.; Peck, A. I.; Pelan, S.; Phillimore, B.; Porter, K. M.; Rice, C. M.; Searle, S.; Sehra, H. K.; Shownkeen, R.; Skuce, C. D.; Smith, M.; Steward, C. A.; Sycamore, N.; Tester, J.; Thomas, D. W.; Tracey, A.; Tromans, A.; Tubby, B.; Wall, M.; Wallis, J. M.; West, A. P.; Whitehead, S. L.; Willey, D. L.; Wilming, L.; Wray, P. W.; Wright, M. W.; Young, L.; Coulson, A.; Durbin, R.; Hubbard, T.; Sulston, J. E.; Beck, S.; Bentley, D. R.; Rogers, J.; Ross, M. T.

The DNA sequence and analysis of human chromosome 13

A. Dunham (), L. H. Matthews, J. Burton, J. L. Ashurst, K. L. Howe, K. J. Ashcroft, D. M. Beare, D. C. Burford, S. E. Hunt, S. Griffiths-Jones, M. C. Jones, S. J. Keenan, K. Oliver, C. E. Scott, R. Ainscough, J. P. Almeida, K. D. Ambrose, D. T. Andrews, R. I. S. Ashwell, A. K. Babbage, C. L. Bagguley, J. Bailey, R. Bannerjee, K. F. Barlow, K. Bates, H. Beasley, C. P. Bird, S. Bray-Allen, A. J. Brown, J. Y. Brown, W. Burrill, C. Carder, N. P. Carter, J. C. Chapman, M. E. Clamp, S. Y. Clark, G. Clarke, C. M. Clee, S. C. M. Clegg, V. Cobley, J. E. Collins, N. Corby, G. J. Coville, P. Deloukas, P. Dhami, I. Dunham, M. Dunn, M. E. Earthrowl, A. G. Ellington, L. Faulkner, A. G. Frankish, J. Frankland, L. French, P. Garner, J. Garnett, J. G. R. Gilbert, C. J. Gilson, J. Ghori, D. V. Grafham, S. M. Gribble, C. Griffiths, R. E. Hall, S. Hammond, J. L. Harley, E. A. Hart, P. D. Heath, P. J. Howden, E. J. Huckle, P. J. Hunt, A. R. Hunt, C. Johnson, D. Johnson, M. Kay, A. M. Kimberley, A. King, G. K. Laird, C. J. Langford, S. Lawlor, D. A. Leongamornlert, D. M. Lloyd, C. Lloyd, J. E. Loveland, J. Lovell, S. Martin, M. Mashreghi-Mohammadi, S. J. McLaren, A. McMurray, S. Milne, M. J. F. Moore, T. Nickerson, S. A. Palmer, A. V. Pearce, A. I. Peck, S. Pelan, B. Phillimore, K. M. Porter, C. M. Rice, S. Searle, H. K. Sehra, R. Shownkeen, C. D. Skuce, M. Smith, C. A. Steward, N. Sycamore, J. Tester, D. W. Thomas, A. Tracey, A. Tromans, B. Tubby, M. Wall, J. M. Wallis, A. P. West, S. L. Whitehead, D. L. Willey, L. Wilming, P. W. Wray, M. W. Wright, L. Young, A. Coulson, R. Durbin, T. Hubbard, J. E. Sulston, S. Beck, D. R. Bentley, J. Rogers and M. T. Ross
Additional contact information
A. Dunham: The Wellcome Trust Sanger Institute
L. H. Matthews: The Wellcome Trust Sanger Institute
J. Burton: The Wellcome Trust Sanger Institute
J. L. Ashurst: The Wellcome Trust Sanger Institute
K. L. Howe: The Wellcome Trust Sanger Institute
K. J. Ashcroft: The Wellcome Trust Sanger Institute
D. M. Beare: The Wellcome Trust Sanger Institute
D. C. Burford: The Wellcome Trust Sanger Institute
S. E. Hunt: The Wellcome Trust Sanger Institute
S. Griffiths-Jones: The Wellcome Trust Sanger Institute
M. C. Jones: The Wellcome Trust Sanger Institute
S. J. Keenan: The Wellcome Trust Sanger Institute
K. Oliver: The Wellcome Trust Sanger Institute
C. E. Scott: The Wellcome Trust Sanger Institute
R. Ainscough: The Wellcome Trust Sanger Institute
J. P. Almeida: The Wellcome Trust Sanger Institute
K. D. Ambrose: The Wellcome Trust Sanger Institute
D. T. Andrews: The Wellcome Trust Sanger Institute
R. I. S. Ashwell: The Wellcome Trust Sanger Institute
A. K. Babbage: The Wellcome Trust Sanger Institute
C. L. Bagguley: The Wellcome Trust Sanger Institute
J. Bailey: The Wellcome Trust Sanger Institute
R. Bannerjee: The Wellcome Trust Sanger Institute
K. F. Barlow: The Wellcome Trust Sanger Institute
K. Bates: The Wellcome Trust Sanger Institute
H. Beasley: The Wellcome Trust Sanger Institute
C. P. Bird: The Wellcome Trust Sanger Institute
S. Bray-Allen: The Wellcome Trust Sanger Institute
A. J. Brown: The Wellcome Trust Sanger Institute
J. Y. Brown: The Wellcome Trust Sanger Institute
W. Burrill: The Wellcome Trust Sanger Institute
C. Carder: The Wellcome Trust Sanger Institute
N. P. Carter: The Wellcome Trust Sanger Institute
J. C. Chapman: The Wellcome Trust Sanger Institute
M. E. Clamp: The Wellcome Trust Sanger Institute
S. Y. Clark: The Wellcome Trust Sanger Institute
G. Clarke: The Wellcome Trust Sanger Institute
C. M. Clee: The Wellcome Trust Sanger Institute
S. C. M. Clegg: The Wellcome Trust Sanger Institute
V. Cobley: The Wellcome Trust Sanger Institute
J. E. Collins: The Wellcome Trust Sanger Institute
N. Corby: The Wellcome Trust Sanger Institute
G. J. Coville: The Wellcome Trust Sanger Institute
P. Deloukas: The Wellcome Trust Sanger Institute
P. Dhami: The Wellcome Trust Sanger Institute
I. Dunham: The Wellcome Trust Sanger Institute
M. Dunn: The Wellcome Trust Sanger Institute
M. E. Earthrowl: The Wellcome Trust Sanger Institute
A. G. Ellington: The Wellcome Trust Sanger Institute
L. Faulkner: The Wellcome Trust Sanger Institute
A. G. Frankish: The Wellcome Trust Sanger Institute
J. Frankland: The Wellcome Trust Sanger Institute
L. French: The Wellcome Trust Sanger Institute
P. Garner: The Wellcome Trust Sanger Institute
J. Garnett: The Wellcome Trust Sanger Institute
J. G. R. Gilbert: The Wellcome Trust Sanger Institute
C. J. Gilson: The Wellcome Trust Sanger Institute
J. Ghori: The Wellcome Trust Sanger Institute
D. V. Grafham: The Wellcome Trust Sanger Institute
S. M. Gribble: The Wellcome Trust Sanger Institute
C. Griffiths: The Wellcome Trust Sanger Institute
R. E. Hall: The Wellcome Trust Sanger Institute
S. Hammond: The Wellcome Trust Sanger Institute
J. L. Harley: The Wellcome Trust Sanger Institute
E. A. Hart: The Wellcome Trust Sanger Institute
P. D. Heath: The Wellcome Trust Sanger Institute
P. J. Howden: The Wellcome Trust Sanger Institute
E. J. Huckle: The Wellcome Trust Sanger Institute
P. J. Hunt: The Wellcome Trust Sanger Institute
A. R. Hunt: The Wellcome Trust Sanger Institute
C. Johnson: The Wellcome Trust Sanger Institute
D. Johnson: The Wellcome Trust Sanger Institute
M. Kay: The Wellcome Trust Sanger Institute
A. M. Kimberley: The Wellcome Trust Sanger Institute
A. King: The Wellcome Trust Sanger Institute
G. K. Laird: The Wellcome Trust Sanger Institute
C. J. Langford: The Wellcome Trust Sanger Institute
S. Lawlor: The Wellcome Trust Sanger Institute
D. A. Leongamornlert: The Wellcome Trust Sanger Institute
D. M. Lloyd: The Wellcome Trust Sanger Institute
C. Lloyd: The Wellcome Trust Sanger Institute
J. E. Loveland: The Wellcome Trust Sanger Institute
J. Lovell: The Wellcome Trust Sanger Institute
S. Martin: The Wellcome Trust Sanger Institute
M. Mashreghi-Mohammadi: The Wellcome Trust Sanger Institute
S. J. McLaren: The Wellcome Trust Sanger Institute
A. McMurray: The Wellcome Trust Sanger Institute
S. Milne: The Wellcome Trust Sanger Institute
M. J. F. Moore: The Wellcome Trust Sanger Institute
T. Nickerson: The Wellcome Trust Sanger Institute
S. A. Palmer: The Wellcome Trust Sanger Institute
A. V. Pearce: The Wellcome Trust Sanger Institute
A. I. Peck: The Wellcome Trust Sanger Institute
S. Pelan: The Wellcome Trust Sanger Institute
B. Phillimore: The Wellcome Trust Sanger Institute
K. M. Porter: The Wellcome Trust Sanger Institute
C. M. Rice: The Wellcome Trust Sanger Institute
S. Searle: The Wellcome Trust Sanger Institute
H. K. Sehra: The Wellcome Trust Sanger Institute
R. Shownkeen: The Wellcome Trust Sanger Institute
C. D. Skuce: The Wellcome Trust Sanger Institute
M. Smith: The Wellcome Trust Sanger Institute
C. A. Steward: The Wellcome Trust Sanger Institute
N. Sycamore: The Wellcome Trust Sanger Institute
J. Tester: The Wellcome Trust Sanger Institute
D. W. Thomas: The Wellcome Trust Sanger Institute
A. Tracey: The Wellcome Trust Sanger Institute
A. Tromans: The Wellcome Trust Sanger Institute
B. Tubby: The Wellcome Trust Sanger Institute
M. Wall: The Wellcome Trust Sanger Institute
J. M. Wallis: The Wellcome Trust Sanger Institute
A. P. West: The Wellcome Trust Sanger Institute
S. L. Whitehead: The Wellcome Trust Sanger Institute
D. L. Willey: The Wellcome Trust Sanger Institute
L. Wilming: The Wellcome Trust Sanger Institute
P. W. Wray: The Wellcome Trust Sanger Institute
M. W. Wright: HUGO Gene Nomenclature Committee, The Galton Laboratory
L. Young: The Wellcome Trust Sanger Institute
A. Coulson: The Wellcome Trust Sanger Institute
R. Durbin: The Wellcome Trust Sanger Institute
T. Hubbard: The Wellcome Trust Sanger Institute
J. E. Sulston: The Wellcome Trust Sanger Institute
S. Beck: The Wellcome Trust Sanger Institute
D. R. Bentley: The Wellcome Trust Sanger Institute
J. Rogers: The Wellcome Trust Sanger Institute
M. T. Ross: The Wellcome Trust Sanger Institute

Nature, 2004, vol. 428, issue 6982, 522-528

Abstract: Abstract Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.

Date: 2004
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DOI: 10.1038/nature02379

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