Cdc42 and mDia3 regulate microtubule attachment to kinetochores

Shingo Yasuda, Fabian Oceguera-Yanez, Takayuki Kato, Muneo Okamoto, Shigenobu Yonemura, Yasuhiko Terada, Toshimasa Ishizaki and Shuh Narumiya ()
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Shingo Yasuda: Kyoto University Faculty of Medicine
Fabian Oceguera-Yanez: Kyoto University Faculty of Medicine
Takayuki Kato: Kyoto University Faculty of Medicine
Muneo Okamoto: Kyoto University Faculty of Medicine
Shigenobu Yonemura: RIKEN Center for Developmental Biology
Yasuhiko Terada: University of Minnesota
Toshimasa Ishizaki: Kyoto University Faculty of Medicine
Shuh Narumiya: Kyoto University Faculty of Medicine

Nature, 2004, vol. 428, issue 6984, 767-771

Abstract: Abstract During mitosis, the mitotic spindle, a bipolar structure composed of microtubules (MTs) and associated motor proteins1,2, segregates sister chromatids to daughter cells. Initially some MTs emanating from one centrosome attach to the kinetochore at the centromere of one of the duplicated chromosomes. This attachment allows rapid poleward movement of the bound chromosome. Subsequent attachment of the sister kinetochore to MTs growing from the other centrosome results in the bi-orientation of the chromosome, in which interactions between kinetochores and the plus ends of MTs are formed and stabilized2. These processes ensure alignment of chromosomes during metaphase and their correct segregation during anaphase. Although many proteins constituting the kinetochore have been identified and extensively studied, the signalling responsible for MT capture and stabilization is unclear1,2. Small GTPases of the Rho family regulate cell morphogenesis by organizing the actin cytoskeleton and regulating MT alignment and stabilization3. We now show that one member of this family, Cdc42, and its effector, mDia3, regulate MT attachment to kinetochores.

Date: 2004
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DOI: 10.1038/nature02452

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