Bacterial disease resistance in Arabidopsis through flagellin perception

Cyril Zipfel, Silke Robatzek, Lionel Navarro, Edward J. Oakeley, Jonathan D. G. Jones, Georg Felix and Thomas Boller ()
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Cyril Zipfel: Friedrich Miescher Institute for Biomedical Research
Silke Robatzek: Friedrich Miescher Institute for Biomedical Research
Lionel Navarro: The Sainsbury Laboratory, John Innes Centre, Colney Lane
Edward J. Oakeley: Friedrich Miescher Institute for Biomedical Research
Jonathan D. G. Jones: The Sainsbury Laboratory, John Innes Centre, Colney Lane
Georg Felix: Friedrich Miescher Institute for Biomedical Research
Thomas Boller: Friedrich Miescher Institute for Biomedical Research

Nature, 2004, vol. 428, issue 6984, 764-767

Abstract: Abstract Plants and animals recognize microbial invaders by detecting pathogen-associated molecular patterns (PAMPs)1,2,3,4,5 such as flagellin6,7,8,9,10. However, the importance of flagellin perception for disease resistance has, until now, not been demonstrated7,8,9,10,11. Here we show that treatment of plants with flg22, a peptide representing the elicitor-active epitope of flagellin6, induces the expression of numerous defence-related genes and triggers resistance to pathogenic bacteria in wild-type plants, but not in plants carrying mutations in the flagellin receptor gene FLS2. This induced resistance seems to be independent of salicylic acid, jasmonic acid and ethylene signalling. Wild-type and fls2 mutants both display enhanced resistance when treated with crude bacterial extracts, even devoid of elicitor-active flagellin, indicating the existence of functional perception systems for PAMPs other than flagellin. Although fls2 mutant plants are as susceptible as the wild type when bacteria are infiltrated into leaves, they are more susceptible to the pathogen Pseudomonas syringae pv. tomato DC3000 when it is sprayed on the leaf surface. Thus, flagellin perception restricts bacterial invasion, probably at an early step, and contributes to the plant's disease resistance.

Date: 2004
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DOI: 10.1038/nature02485

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