The DNA sequence and comparative analysis of human chromosome 10

Deloukas, P.; Earthrowl, M. E.; Grafham, D. V.; Rubenfield, M.; French, L.; Steward, C. A.; Sims, S. K.; Jones, M. C.; Searle, S.; Scott, C.; Howe, K.; Hunt, S. E.; Andrews, T. D.; Gilbert, J. G. R.; Swarbreck, D.; Ashurst, J. L.; Taylor, A.; Battles, J.; Bird, C. P.; Ainscough, R.; Almeida, J. P.; Ashwell, R. I. S.; Ambrose, K. D.; Babbage, A. K.; Bagguley, C. L.; Bailey, J.; Banerjee, R.; Bates, K.; Beasley, H.; Bray-Allen, S.; Brown, A. J.; Brown, J. Y.; Burford, D. C.; Burrill, W.; Burton, J.; Cahill, P.; Camire, D.; Carter, N. P.; Chapman, J. C.; Clark, S. Y.; Clarke, G.; Clee, C. M.; Clegg, S.; Corby, N.; Coulson, A.; Dhami, P.; Dutta, I.; Dunn, M.; Faulkner, L.; Frankish, A.; Frankland, J. A.; Garner, P.; Garnett, J.; Gribble, S.; Griffiths, C.; Grocock, R.; Gustafson, E.; Hammond, S.; Harley, J. L.; Hart, E.; Heath, P. D.; Ho, T. P.; Hopkins, B.; Horne, J.; Howden, P. J.; Huckle, E.; Hynds, C.; Johnson, C.; Johnson, D.; Kana, A.; Kay, M.; Kimberley, A. M.; Kershaw, J. K.; Kokkinaki, M.; Laird, G. K.; Lawlor, S.; Lee, H. M.; Leongamornlert, D. A.; Laird, G.; Lloyd, C.; Lloyd, D. M.; Loveland, J.; Lovell, J.; McLaren, S.; McLay, K. E.; McMurray, A.; Mashreghi-Mohammadi, M.; Matthews, L.; Milne, S.; Nickerson, T.; Nguyen, M.; Overton-Larty, E.; Palmer, S. A.; Pearce, A. V.; Peck, A. I.; Pelan, S.; Phillimore, B.; Porter, K.; Rice, C. M.; Rogosin, A.; Ross, M. T.; Sarafidou, T.; Sehra, H. K.; Shownkeen, R.; Skuce, C. D.; Smith, M.; Standring, L.; Sycamore, N.; Tester, J.; Thorpe, A.; Torcasso, W.; Tracey, A.; Tromans, A.; Tsolas, J.; Wall, M.; Walsh, J.; Wang, H.; Weinstock, K.; West, A. P.; Willey, D. L.; Whitehead, S. L.; Wilming, L.; Wray, P. W.; Young, L.; Chen, Y.; Lovering, R. C.; Moschonas, N. K.; Siebert, R.; Fechtel, K.; Bentley, D.; Durbin, R.; Hubbard, T.; Doucette-Stamm, L.; Beck, S.; Smith, D. R.; Rogers, J.

The DNA sequence and comparative analysis of human chromosome 10

P. Deloukas (), M. E. Earthrowl, D. V. Grafham, M. Rubenfield, L. French, C. A. Steward, S. K. Sims, M. C. Jones, S. Searle, C. Scott, K. Howe, S. E. Hunt, T. D. Andrews, J. G. R. Gilbert, D. Swarbreck, J. L. Ashurst, A. Taylor, J. Battles, C. P. Bird, R. Ainscough, J. P. Almeida, R. I. S. Ashwell, K. D. Ambrose, A. K. Babbage, C. L. Bagguley, J. Bailey, R. Banerjee, K. Bates, H. Beasley, S. Bray-Allen, A. J. Brown, J. Y. Brown, D. C. Burford, W. Burrill, J. Burton, P. Cahill, D. Camire, N. P. Carter, J. C. Chapman, S. Y. Clark, G. Clarke, C. M. Clee, S. Clegg, N. Corby, A. Coulson, P. Dhami, I. Dutta, M. Dunn, L. Faulkner, A. Frankish, J. A. Frankland, P. Garner, J. Garnett, S. Gribble, C. Griffiths, R. Grocock, E. Gustafson, S. Hammond, J. L. Harley, E. Hart, P. D. Heath, T. P. Ho, B. Hopkins, J. Horne, P. J. Howden, E. Huckle, C. Hynds, C. Johnson, D. Johnson, A. Kana, M. Kay, A. M. Kimberley, J. K. Kershaw, M. Kokkinaki, G. K. Laird, S. Lawlor, H. M. Lee, D. A. Leongamornlert, G. Laird, C. Lloyd, D. M. Lloyd, J. Loveland, J. Lovell, S. McLaren, K. E. McLay, A. McMurray, M. Mashreghi-Mohammadi, L. Matthews, S. Milne, T. Nickerson, M. Nguyen, E. Overton-Larty, S. A. Palmer, A. V. Pearce, A. I. Peck, S. Pelan, B. Phillimore, K. Porter, C. M. Rice, A. Rogosin, M. T. Ross, T. Sarafidou, H. K. Sehra, R. Shownkeen, C. D. Skuce, M. Smith, L. Standring, N. Sycamore, J. Tester, A. Thorpe, W. Torcasso, A. Tracey, A. Tromans, J. Tsolas, M. Wall, J. Walsh, H. Wang, K. Weinstock, A. P. West, D. L. Willey, S. L. Whitehead, L. Wilming, P. W. Wray, L. Young, Y. Chen, R. C. Lovering, N. K. Moschonas, R. Siebert, K. Fechtel, D. Bentley, R. Durbin, T. Hubbard, L. Doucette-Stamm, S. Beck, D. R. Smith and J. Rogers
Additional contact information
P. Deloukas: The Wellcome Trust Sanger Institute
M. E. Earthrowl: The Wellcome Trust Sanger Institute
D. V. Grafham: The Wellcome Trust Sanger Institute
M. Rubenfield: Genome Therapeutics Corporation
L. French: The Wellcome Trust Sanger Institute
C. A. Steward: The Wellcome Trust Sanger Institute
S. K. Sims: The Wellcome Trust Sanger Institute
M. C. Jones: The Wellcome Trust Sanger Institute
S. Searle: The Wellcome Trust Sanger Institute
C. Scott: The Wellcome Trust Sanger Institute
K. Howe: The Wellcome Trust Sanger Institute
S. E. Hunt: The Wellcome Trust Sanger Institute
T. D. Andrews: The Wellcome Trust Sanger Institute
J. G. R. Gilbert: The Wellcome Trust Sanger Institute
D. Swarbreck: The Wellcome Trust Sanger Institute
J. L. Ashurst: The Wellcome Trust Sanger Institute
A. Taylor: The Wellcome Trust Sanger Institute
J. Battles: Genome Therapeutics Corporation
C. P. Bird: The Wellcome Trust Sanger Institute
R. Ainscough: The Wellcome Trust Sanger Institute
J. P. Almeida: The Wellcome Trust Sanger Institute
R. I. S. Ashwell: The Wellcome Trust Sanger Institute
K. D. Ambrose: The Wellcome Trust Sanger Institute
A. K. Babbage: The Wellcome Trust Sanger Institute
C. L. Bagguley: The Wellcome Trust Sanger Institute
J. Bailey: The Wellcome Trust Sanger Institute
R. Banerjee: The Wellcome Trust Sanger Institute
K. Bates: The Wellcome Trust Sanger Institute
H. Beasley: The Wellcome Trust Sanger Institute
S. Bray-Allen: The Wellcome Trust Sanger Institute
A. J. Brown: The Wellcome Trust Sanger Institute
J. Y. Brown: The Wellcome Trust Sanger Institute
D. C. Burford: The Wellcome Trust Sanger Institute
W. Burrill: The Wellcome Trust Sanger Institute
J. Burton: The Wellcome Trust Sanger Institute
P. Cahill: Genome Therapeutics Corporation
D. Camire: Genome Therapeutics Corporation
N. P. Carter: The Wellcome Trust Sanger Institute
J. C. Chapman: The Wellcome Trust Sanger Institute
S. Y. Clark: The Wellcome Trust Sanger Institute
G. Clarke: The Wellcome Trust Sanger Institute
C. M. Clee: The Wellcome Trust Sanger Institute
S. Clegg: The Wellcome Trust Sanger Institute
N. Corby: The Wellcome Trust Sanger Institute
A. Coulson: The Wellcome Trust Sanger Institute
P. Dhami: The Wellcome Trust Sanger Institute
I. Dutta: The Wellcome Trust Sanger Institute
M. Dunn: The Wellcome Trust Sanger Institute
L. Faulkner: The Wellcome Trust Sanger Institute
A. Frankish: The Wellcome Trust Sanger Institute
J. A. Frankland: The Wellcome Trust Sanger Institute
P. Garner: The Wellcome Trust Sanger Institute
J. Garnett: The Wellcome Trust Sanger Institute
S. Gribble: The Wellcome Trust Sanger Institute
C. Griffiths: The Wellcome Trust Sanger Institute
R. Grocock: The Wellcome Trust Sanger Institute
E. Gustafson: Genome Therapeutics Corporation
S. Hammond: The Wellcome Trust Sanger Institute
J. L. Harley: The Wellcome Trust Sanger Institute
E. Hart: The Wellcome Trust Sanger Institute
P. D. Heath: The Wellcome Trust Sanger Institute
T. P. Ho: Genome Therapeutics Corporation
B. Hopkins: The Wellcome Trust Sanger Institute
J. Horne: Genome Therapeutics Corporation
P. J. Howden: The Wellcome Trust Sanger Institute
E. Huckle: The Wellcome Trust Sanger Institute
C. Hynds: Genome Therapeutics Corporation
C. Johnson: The Wellcome Trust Sanger Institute
D. Johnson: The Wellcome Trust Sanger Institute
A. Kana: Genome Therapeutics Corporation
M. Kay: The Wellcome Trust Sanger Institute
A. M. Kimberley: The Wellcome Trust Sanger Institute
J. K. Kershaw: The Wellcome Trust Sanger Institute
M. Kokkinaki: University of Crete & Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology
G. K. Laird: The Wellcome Trust Sanger Institute
S. Lawlor: The Wellcome Trust Sanger Institute
H. M. Lee: Genome Therapeutics Corporation
D. A. Leongamornlert: The Wellcome Trust Sanger Institute
G. Laird: The Wellcome Trust Sanger Institute
C. Lloyd: The Wellcome Trust Sanger Institute
D. M. Lloyd: The Wellcome Trust Sanger Institute
J. Loveland: The Wellcome Trust Sanger Institute
J. Lovell: The Wellcome Trust Sanger Institute
S. McLaren: The Wellcome Trust Sanger Institute
K. E. McLay: The Wellcome Trust Sanger Institute
A. McMurray: The Wellcome Trust Sanger Institute
M. Mashreghi-Mohammadi: The Wellcome Trust Sanger Institute
L. Matthews: The Wellcome Trust Sanger Institute
S. Milne: The Wellcome Trust Sanger Institute
T. Nickerson: The Wellcome Trust Sanger Institute
M. Nguyen: Genome Therapeutics Corporation
E. Overton-Larty: The Wellcome Trust Sanger Institute
S. A. Palmer: The Wellcome Trust Sanger Institute
A. V. Pearce: The Wellcome Trust Sanger Institute
A. I. Peck: The Wellcome Trust Sanger Institute
S. Pelan: The Wellcome Trust Sanger Institute
B. Phillimore: The Wellcome Trust Sanger Institute
K. Porter: The Wellcome Trust Sanger Institute
C. M. Rice: The Wellcome Trust Sanger Institute
A. Rogosin: Genome Therapeutics Corporation
M. T. Ross: The Wellcome Trust Sanger Institute
T. Sarafidou: University of Crete & Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology
H. K. Sehra: The Wellcome Trust Sanger Institute
R. Shownkeen: The Wellcome Trust Sanger Institute
C. D. Skuce: The Wellcome Trust Sanger Institute
M. Smith: The Wellcome Trust Sanger Institute
L. Standring: Genome Therapeutics Corporation
N. Sycamore: The Wellcome Trust Sanger Institute
J. Tester: The Wellcome Trust Sanger Institute
A. Thorpe: The Wellcome Trust Sanger Institute
W. Torcasso: Genome Therapeutics Corporation
A. Tracey: The Wellcome Trust Sanger Institute
A. Tromans: The Wellcome Trust Sanger Institute
J. Tsolas: Genome Therapeutics Corporation
M. Wall: The Wellcome Trust Sanger Institute
J. Walsh: Genome Therapeutics Corporation
H. Wang: Genome Therapeutics Corporation
K. Weinstock: Genome Therapeutics Corporation
A. P. West: The Wellcome Trust Sanger Institute
D. L. Willey: The Wellcome Trust Sanger Institute
S. L. Whitehead: The Wellcome Trust Sanger Institute
L. Wilming: The Wellcome Trust Sanger Institute
P. W. Wray: The Wellcome Trust Sanger Institute
L. Young: The Wellcome Trust Sanger Institute
Y. Chen: European Bioinformatics Institute (EBI)
R. C. Lovering: University College London
N. K. Moschonas: University of Crete & Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology
R. Siebert: University Hospital Schleswig-Holstein Campus Kiel
K. Fechtel: Genome Therapeutics Corporation
D. Bentley: The Wellcome Trust Sanger Institute
R. Durbin: The Wellcome Trust Sanger Institute
T. Hubbard: The Wellcome Trust Sanger Institute
L. Doucette-Stamm: Genome Therapeutics Corporation
S. Beck: The Wellcome Trust Sanger Institute
D. R. Smith: Genome Therapeutics Corporation
J. Rogers: The Wellcome Trust Sanger Institute

Nature, 2004, vol. 429, issue 6990, 375-381

Abstract: Abstract The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. Sequence annotation revealed 1,357 genes, of which 816 are protein coding, and 430 are pseudogenes. We observed widespread occurrence of overlapping coding genes (either strand) and identified 67 antisense transcripts. Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. Multispecies comparative analysis indicated that we can readily annotate the protein-coding genes with current resources. We estimate that over 95% of all coding exons were identified in this study. Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.

Date: 2004
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature02462 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:429:y:2004:i:6990:d:10.1038_nature02462

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature02462

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().