Does gut hormone PYY3–36 decrease food intake in rodents?

M. Tschöp (), T. R. Castañeda, H. G. Joost, C. Thöne-Reineke, S. Ortmann, S. Klaus, M. M. Hagan, P. C. Chandler, K. D. Oswald, S. C. Benoit, R. J. Seeley, K. P. Kinzig, T. H. Moran, A. G. Beck-Sickinger, N. Koglin, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. Holch, D. B. Allison, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, M. Schindler, K. Arndt, K. Rudolf, M. Mark, X. Y. Deng, D. C. Withcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Craney, D. Flora, D. Smiley and M. L. Heiman
Additional contact information
M. Tschöp: University of Cincinnati Genome Research Institute
T. R. Castañeda: University of Cincinnati Genome Research Institute
H. G. Joost: German Institute of Human Nutrition
C. Thöne-Reineke: Center for Cardiovascular Research, Institute for Pharmacology and Toxicology, Charité University Hospital
S. Ortmann: German Institute of Human Nutrition
S. Klaus: German Institute of Human Nutrition
M. M. Hagan: University of Alabama at Birmingham
P. C. Chandler: University of Alabama at Birmingham
K. D. Oswald: University of Alabama at Birmingham
S. C. Benoit: University of Cincinnati Genome Research Institute
R. J. Seeley: University of Cincinnati Genome Research Institute
K. P. Kinzig: Johns Hopkins University School of Medicine
T. H. Moran: Johns Hopkins University School of Medicine
A. G. Beck-Sickinger: Institute of Biochemistry, University of Leipzig
N. Koglin: Institute of Biochemistry, University of Leipzig
R. J. Rodgers: Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds
J. E. Blundell: Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds
Y. Ishii: Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds
A. H. Beattie: Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds
P. Holch: Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds
D. B. Allison: Section on Statistical Genetics, University of Alabama at Birmingham
K. Raun: Novo Nordisk A/S, Discovery
K. Madsen: Novo Nordisk A/S, Discovery
B. S. Wulff: Novo Nordisk A/S, Discovery
C. E. Stidsen: Novo Nordisk A/S, Discovery
M. Birringer: Peptides and Elephants GmbH
O. J. Kreuzer: Peptides and Elephants GmbH
M. Schindler: Boehringer-Ingelheim Pharma GmbH and Co. KG
K. Arndt: Boehringer-Ingelheim Pharma GmbH and Co. KG
K. Rudolf: Boehringer-Ingelheim Pharma GmbH and Co. KG
M. Mark: Boehringer-Ingelheim Pharma GmbH and Co. KG
X. Y. Deng: Hepatology and Nutrition, University of Pittsburgh
D. C. Withcomb: Hepatology and Nutrition, University of Pittsburgh
H. Halem: Biomeasure Incorporated/Ipsen Group
J. Taylor: Biomeasure Incorporated/Ipsen Group
J. Dong: Biomeasure Incorporated/Ipsen Group
R. Datta: Biomeasure Incorporated/Ipsen Group
M. Culler: Biomeasure Incorporated/Ipsen Group
S. Craney: Eli Lilly & Co. Research Laboratories
D. Flora: Eli Lilly & Co. Research Laboratories
D. Smiley: Eli Lilly & Co. Research Laboratories
M. L. Heiman: Eli Lilly & Co. Research Laboratories

Nature, 2004, vol. 430, issue 6996, 1-3

Abstract: Abstract Arising from: R. L. Batterham et al. Nature 418, 650–654 (2002); Batterham et al. reply Batterham et al. report that the gut peptide hormone PYY3–36 decreases food intake and body-weight gain in rodents1, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al.1 cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3–36.

Date: 2004
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DOI: 10.1038/nature02665

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