Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Jason G. Wood, Blanka Rogina, Siva Lavu, Konrad Howitz, Stephen L. Helfand (), Marc Tatar () and David Sinclair ()
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Jason G. Wood: Harvard Medical School
Blanka Rogina: University of Connecticut Health Center
Siva Lavu: Harvard Medical School
Konrad Howitz: BIOMOL Research Laboratories, Inc.
Stephen L. Helfand: University of Connecticut Health Center
Marc Tatar: Brown University
David Sinclair: Harvard Medical School

Nature, 2004, vol. 430, issue 7000, 686-689

Abstract: Abstract Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases2,3. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast4. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.

Date: 2004
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DOI: 10.1038/nature02789

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