Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

Heather L. True, Ilana Berlin and Susan L. Lindquist ()
Additional contact information
Heather L. True: Whitehead Institute for Biomedical Research
Ilana Berlin: Whitehead Institute for Biomedical Research
Susan L. Lindquist: Whitehead Institute for Biomedical Research

Nature, 2004, vol. 431, issue 7005, 184-187

Abstract: Abstract Phenotypic plasticity and the exposure of hidden genetic variation both affect the survival and evolution of new traits1,2,3, but their contributing molecular mechanisms are largely unknown. A single factor, the yeast prion [PSI+], may exert a profound effect on both4. [PSI+] is a conserved, protein-based genetic element that is formed by a change in the conformation and function of the translation termination factor Sup35p5, and is transmitted from mother to progeny. Curing cells of [PSI+] alters their survival in different growth conditions and produces a spectrum of phenotypes in different genetic backgrounds4. Here we show, by examining three plausible explanations for this phenotypic diversity, that all traits tested involved [PSI+]-mediated read-through of nonsense codons. Notably, the phenotypes analysed were genetically complex, and genetic re-assortment frequently converted [PSI+]-dependent phenotypes to stable traits that persisted in the absence of [PSI+]. Thus, [PSI+] provides a temporary survival advantage under diverse conditions, increasing the likelihood that new traits will become fixed by subsequent genetic change. As an epigenetic mechanism that globally affects the relationship between genotype and phenotype, [PSI+] expands the conceptual framework for phenotypic plasticity, provides a one-step mechanism for the acquisition of complex traits and affords a route to the genetic assimilation of initially transient epigenetic traits.

Date: 2004
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature02885 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:431:y:2004:i:7005:d:10.1038_nature02885

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature02885

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().