Revealing the world of RNA interference

Craig C. Mello () and Darryl Conte
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Craig C. Mello: Howard Hughes Medical Institute, University of Massachusetts Medical School
Darryl Conte: Program in Molecular Medicine, University of Massachusetts Medical School

Nature, 2004, vol. 431, issue 7006, 338-342

Abstract: Abstract The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena.

Date: 2004
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DOI: 10.1038/nature02872

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