Mechanisms of gene silencing by double-stranded RNA

Gunter Meister and Thomas Tuschl ()
Additional contact information
Gunter Meister: Laboratory of RNA Molecular Biology, The Rockefeller University
Thomas Tuschl: Laboratory of RNA Molecular Biology, The Rockefeller University

Nature, 2004, vol. 431, issue 7006, 343-349

Abstract: Abstract Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene silencing that are collectively referred to as RNA silencing or RNA interference. A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure. These short dsRNAs guide RNA silencing by specific and distinct mechanisms. Many components of the RNA silencing machinery still need to be identified and characterized, but a more complete understanding of the process is imminent.

Date: 2004
References: Add references at CitEc
Citations: View citations in EconPapers (9)

Downloads: (external link)
https://www.nature.com/articles/nature02873 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:431:y:2004:i:7006:d:10.1038_nature02873

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature02873

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().