Intragenic ERBB2 kinase mutations in tumours

Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker, Andy Barthorpe, Matthew Blow, Lisa Brackenbury, Adam Butler, Oliver Clarke, Jennifer Cole, Ed Dicks, Angus Dike, Anja Drozd, Ken Edwards, Simon Forbes, Rebecca Foster, Kristian Gray, Chris Greenman, Kelly Halliday, Katy Hills, Vivienne Kosmidou, Richard Lugg, Andy Menzies, Janet Perry, Robert Petty, Keiran Raine, Lewis Ratford, Rebecca Shepherd, Alexandra Small, Yvonne Stephens, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S. Cooper, Adrienne M. Flanagan, Margaret Knowles, Suet Y. Leung, David N. Louis, Leendert H. J. Looijenga, Bruce Malkowicz, Marco A. Pierotti, Bin Teh, Georgia Chenevix-Trench, Barbara L. Weber, Siu T. Yuen, Grace Harris, Peter Goldstraw, Andrew G. Nicholson, P. Andrew Futreal (), Richard Wooster and Michael R. Stratton
Additional contact information
Philip Stephens: Cancer Genome Project, Wellcome Trust Sanger Institute
Chris Hunter: Cancer Genome Project, Wellcome Trust Sanger Institute
Graham Bignell: Cancer Genome Project, Wellcome Trust Sanger Institute
Sarah Edkins: Cancer Genome Project, Wellcome Trust Sanger Institute
Helen Davies: Cancer Genome Project, Wellcome Trust Sanger Institute
Jon Teague: Cancer Genome Project, Wellcome Trust Sanger Institute
Claire Stevens: Cancer Genome Project, Wellcome Trust Sanger Institute
Sarah O'Meara: Cancer Genome Project, Wellcome Trust Sanger Institute
Raffaella Smith: Cancer Genome Project, Wellcome Trust Sanger Institute
Adrian Parker: Cancer Genome Project, Wellcome Trust Sanger Institute
Andy Barthorpe: Cancer Genome Project, Wellcome Trust Sanger Institute
Matthew Blow: Cancer Genome Project, Wellcome Trust Sanger Institute
Lisa Brackenbury: Cancer Genome Project, Wellcome Trust Sanger Institute
Adam Butler: Cancer Genome Project, Wellcome Trust Sanger Institute
Oliver Clarke: Cancer Genome Project, Wellcome Trust Sanger Institute
Jennifer Cole: Cancer Genome Project, Wellcome Trust Sanger Institute
Ed Dicks: Cancer Genome Project, Wellcome Trust Sanger Institute
Angus Dike: Cancer Genome Project, Wellcome Trust Sanger Institute
Anja Drozd: Cancer Genome Project, Wellcome Trust Sanger Institute
Ken Edwards: Cancer Genome Project, Wellcome Trust Sanger Institute
Simon Forbes: Cancer Genome Project, Wellcome Trust Sanger Institute
Rebecca Foster: Cancer Genome Project, Wellcome Trust Sanger Institute
Kristian Gray: Cancer Genome Project, Wellcome Trust Sanger Institute
Chris Greenman: Cancer Genome Project, Wellcome Trust Sanger Institute
Kelly Halliday: Cancer Genome Project, Wellcome Trust Sanger Institute
Katy Hills: Cancer Genome Project, Wellcome Trust Sanger Institute
Vivienne Kosmidou: Cancer Genome Project, Wellcome Trust Sanger Institute
Richard Lugg: Cancer Genome Project, Wellcome Trust Sanger Institute
Andy Menzies: Cancer Genome Project, Wellcome Trust Sanger Institute
Janet Perry: Cancer Genome Project, Wellcome Trust Sanger Institute
Robert Petty: Cancer Genome Project, Wellcome Trust Sanger Institute
Keiran Raine: Cancer Genome Project, Wellcome Trust Sanger Institute
Lewis Ratford: Cancer Genome Project, Wellcome Trust Sanger Institute
Rebecca Shepherd: Cancer Genome Project, Wellcome Trust Sanger Institute
Alexandra Small: Cancer Genome Project, Wellcome Trust Sanger Institute
Yvonne Stephens: Cancer Genome Project, Wellcome Trust Sanger Institute
Calli Tofts: Cancer Genome Project, Wellcome Trust Sanger Institute
Jennifer Varian: Cancer Genome Project, Wellcome Trust Sanger Institute
Sofie West: Cancer Genome Project, Wellcome Trust Sanger Institute
Sara Widaa: Cancer Genome Project, Wellcome Trust Sanger Institute
Andrew Yates: Cancer Genome Project, Wellcome Trust Sanger Institute
Francis Brasseur: Ludwig Institute for Cancer Research
Colin S. Cooper: Institute of Cancer Research
Adrienne M. Flanagan: Institute of Orthopaedics, University College London
Margaret Knowles: Cancer Research UK Clinical Centre, St James's University Hospital
Suet Y. Leung: Queen Mary Hospital
David N. Louis: Massachusetts General Hospital East, Molecular Pathology Unit
Leendert H. J. Looijenga: Laboratory of Pathology/Experimental Patho-Oncology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute
Bruce Malkowicz: University of Pennsylvania Division of Urology
Marco A. Pierotti: Instituto Nazionale Tumori and FIRC Institute of Molecular Oncology
Bin Teh: Laboratory of Cancer Genetics, Van Andel Research Institute
Georgia Chenevix-Trench: Queensland Institute of Medical Research, Royal Brisbane Hospital
Barbara L. Weber: University of Pennsylvania Cancer Centre
Siu T. Yuen: Queen Mary Hospital
Grace Harris: Royal Brompton Hospital
Peter Goldstraw: Royal Brompton Hospital
Andrew G. Nicholson: Royal Brompton Hospital
P. Andrew Futreal: Cancer Genome Project, Wellcome Trust Sanger Institute
Richard Wooster: Cancer Genome Project, Wellcome Trust Sanger Institute
Michael R. Stratton: Cancer Genome Project, Wellcome Trust Sanger Institute

Nature, 2004, vol. 431, issue 7008, 525-526

Abstract: Abstract The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations.

Date: 2004
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DOI: 10.1038/431525b

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