Coupled oscillators control morning and evening locomotor behaviour of Drosophila

Dan Stoleru, Ying Peng, José Agosto and Michael Rosbash ()
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Dan Stoleru: Brandeis University
Ying Peng: Brandeis University
José Agosto: Brandeis University
Michael Rosbash: Brandeis University

Nature, 2004, vol. 431, issue 7010, 862-868

Abstract: Abstract Daily rhythms of physiology and behaviour are precisely timed by an endogenous circadian clock1,2. These include separate bouts of morning and evening activity, characteristic of Drosophila melanogaster and many other taxa, including mammals3,4,5. Whereas multiple oscillators have long been proposed to orchestrate such complex behavioural programmes6, their nature and interplay have remained elusive. By using cell-specific ablation, we show that the timing of morning and evening activity in Drosophila derives from two distinct groups of circadian neurons: morning activity from the ventral lateral neurons that express the neuropeptide PDF, and evening activity from another group of cells, including the dorsal lateral neurons. Although the two oscillators can function autonomously, cell-specific rescue experiments with circadian clock mutants indicate that they are functionally coupled.

Date: 2004
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DOI: 10.1038/nature02926

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