Neutral evolution of ‘non-coding’ complementary DNAs

Jun Wang, Jianguo Zhang, Hongkun Zheng, Jun Li, Dongyuan Liu, Heng Li, Ram Samudrala, Jun Yu and Gane Ka-Shu Wong ()
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Jun Wang: James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute
Jianguo Zhang: Beijing Institute of Genomics of the Chinese Academy of Sciences
Hongkun Zheng: Beijing Institute of Genomics of the Chinese Academy of Sciences
Jun Li: Beijing Institute of Genomics of the Chinese Academy of Sciences
Dongyuan Liu: Beijing Institute of Genomics of the Chinese Academy of Sciences
Heng Li: Beijing Institute of Genomics of the Chinese Academy of Sciences
Ram Samudrala: Computation Genomics Group, University of Washington
Jun Yu: James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute
Gane Ka-Shu Wong: James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute

Nature, 2004, vol. 431, issue 7010, 1-2

Abstract: Abstract (Arising from: Y. Okazaki et al. Nature 420, 563–573 200210.1038/nature01266 ; Okazaki et al. reply) Okazaki et al. have argued that as many as 15,815 of 33,409 non-redundant mouse complementary DNAs may represent functional RNA genes1, on the basis of their findings that some of these cDNAs are confirmed by expressed sequence tagging and are found near CpG islands or polyadenylation signals2 — although many are expressed at such low levels that they could not be detected by microarray analysis3. We show here that conservation of these ‘non-coding’ cDNAs in rats or humans is no better than in an evolutionarily neutral control. Our results indicate that they are either non-functional or, if they are functional, are specific to a given species.

Date: 2004
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DOI: 10.1038/nature03016

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