Stromal fibroblasts in cancer initiation and progression

Neil A. Bhowmick, Eric G. Neilson and Harold L. Moses ()
Additional contact information
Neil A. Bhowmick: Vanderbilt University School of Medicine
Eric G. Neilson: The Vanderbilt–Ingram Cancer Center, Vanderbilt University School of Medicine
Harold L. Moses: Vanderbilt University School of Medicine

Nature, 2004, vol. 432, issue 7015, 332-337

Abstract: Abstract It is widely accepted that the development of carcinoma — the most common form of human cancer — is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

Date: 2004
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature03096 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:432:y:2004:i:7015:d:10.1038_nature03096

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature03096

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().