Intrinsic tumour suppression

Scott W. Lowe (), Enrique Cepero and Gerard Evan
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Scott W. Lowe: Cold Spring Harbor Laboratory
Enrique Cepero: Cold Spring Harbor Laboratory
Gerard Evan: Cancer Research Institute, University of California at San Francisco

Nature, 2004, vol. 432, issue 7015, 307-315

Abstract: Abstract Mutations that drive uncontrolled cell-cycle progression are requisite events in tumorigenesis. But evolution has installed in the proliferative programmes of mammalian cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or senescence, should proliferation become aberrant. These contingent processes rely on a series of sensors and transducers that act in a coordinated network to target the machinery responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic mutations that disable such networks can have profound and varied effects on tumour evolution, they may leave intact latent tumour-suppressive potential that can be harnessed therapeutically.

Date: 2004
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DOI: 10.1038/nature03098

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