Aneuploidy and cancer

Harith Rajagopalan and Christoph Lengauer ()
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Harith Rajagopalan: The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Christoph Lengauer: The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine

Nature, 2004, vol. 432, issue 7015, 338-341

Abstract: Abstract In contrast to normal cells, aneuploidy — alterations in the number of chromosomes — is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.

Date: 2004
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DOI: 10.1038/nature03099

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