A candidate NAD+ transporter in an intracellular bacterial symbiont related to Chlamydiae

Ilka Haferkamp, Stephan Schmitz-Esser, Nicole Linka, Claude Urbany, Astrid Collingro, Michael Wagner, Matthias Horn and H. Ekkehard Neuhaus ()
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Ilka Haferkamp: Pflanzenphysiologie, Universität Kaiserslautern
Stephan Schmitz-Esser: Institut für Ökologie und Naturschutz, Universität Wien
Nicole Linka: Pflanzenphysiologie, Universität Kaiserslautern
Claude Urbany: Pflanzenphysiologie, Universität Kaiserslautern
Astrid Collingro: Institut für Ökologie und Naturschutz, Universität Wien
Michael Wagner: Institut für Ökologie und Naturschutz, Universität Wien
Matthias Horn: Institut für Ökologie und Naturschutz, Universität Wien
H. Ekkehard Neuhaus: Pflanzenphysiologie, Universität Kaiserslautern

Nature, 2004, vol. 432, issue 7017, 622-625

Abstract: Abstract Bacteria living within eukaryotic cells can be essential for the survival or reproduction of the host1,2 but in other cases are among the most successful pathogens3,4. Environmental Chlamydiae, including strain UWE25, thrive as obligate intracellular symbionts within protozoa; are recently discovered relatives of major bacterial pathogens of humans; and also infect human cells4,5,6,7. Genome analysis of UWE25 predicted that this symbiont is unable to synthesize the universal electron carrier nicotinamide adenine dinucleotide (NAD+)7. Compensation of limited biosynthetic capacity in intracellular bacteria is usually achieved by import of primary metabolites8,9,10,11. Here, we report the identification of a candidate transporter protein from UWE25 that is highly specific for import of NAD+ when synthesized heterologously in Escherichia coli. The discovery of this candidate NAD+/ADP exchanger demonstrates that intact NAD+ molecules can be transported through cytoplasmic membranes. This protein acts together with a newly discovered nucleotide transporter and an ATP/ADP translocase12, and allows UWE25 to exploit its host cell by means of a sophisticated metabolic parasitism.

Date: 2004
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DOI: 10.1038/nature03131

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