Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

Ann-Kristin Mueller, Mehdi Labaied, Stefan H. I. Kappe () and Kai Matuschewski ()
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Ann-Kristin Mueller: Heidelberg University School of Medicine
Mehdi Labaied: Seattle Biomedical Research Institute
Stefan H. I. Kappe: Seattle Biomedical Research Institute
Kai Matuschewski: Heidelberg University School of Medicine

Nature, 2005, vol. 433, issue 7022, 164-167

Abstract: Malaria vaccine hope The prospect of large-scale production of an effective malaria vaccine comes a step closer with publication of a study showing that a vaccine made from a live malaria parasite can protect against infection in a rodent malaria model. When an infected female Anopheles mosquito bites a person, Plasmodium parasite can enter the blood. The Plasmodium used in the successful live vaccine is genetically modified by removing the uis3, gene needed for progression to the next stage of its life cycle, in the liver. Mice injected with these weakened parasites developed immunity against normal infectious Plasmodium. A human vaccine using this gene-deletion approach would need to meet high safety standards, so it is still some way off, but proof that it can work is an important advance.

Date: 2005
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DOI: 10.1038/nature03188

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