Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone

Pan-Young Jeong, Mankil Jung, Yong-Hyeon Yim, Heekyeong Kim, Moonsoo Park, Eunmi Hong, Weontae Lee, Young Hwan Kim, Kun Kim and Young-Ki Paik ()
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Pan-Young Jeong: Department of Biochemistry and Yonsei Proteome Research Center
Mankil Jung: Department of Chemistry
Yong-Hyeon Yim: Korea Research Institute of Standards and Science
Heekyeong Kim: Department of Chemistry
Moonsoo Park: Department of Chemistry
Eunmi Hong: Department of Biochemistry and Yonsei Proteome Research Center
Weontae Lee: Department of Biochemistry and Yonsei Proteome Research Center
Young Hwan Kim: Korea Basic Science Institute
Kun Kim: Yonsei University
Young-Ki Paik: Department of Biochemistry and Yonsei Proteome Research Center

Nature, 2005, vol. 433, issue 7025, 541-545

Abstract: Dauer consequences The dauer form in the nematode C. elegans is a non-ageing stage of the life cycle conducive to survival in adverse conditions such as food shortage. The properties of the natural dauer-inducing pheromone (‘daumone’) that regulates ageing and development in C. elegans have been studied for many years, but its precise biochemical identity remained unknown. Daumone has now been purified and fully characterized and, as predicted, it is a fatty acid derivative. Natural and chemically synthesized daumones equally induce dauer larva formation. This work could lead to novel antinematodal drugs and is relevant to research into ageing and obesity.

Date: 2005
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DOI: 10.1038/nature03201

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