Regulation of cap-dependent translation by eIF4E inhibitory proteins

Joel D. Richter () and Nahum Sonenberg
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Joel D. Richter: University of Massachusetts Medical School
Nahum Sonenberg: McGill University

Nature, 2005, vol. 433, issue 7025, 477-480

Abstract: Abstract Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5′ ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.

Date: 2005
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DOI: 10.1038/nature03205

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