Interaction network containing conserved and essential protein complexes in Escherichia coli

Gareth Butland, José Manuel Peregrín-Alvarez, Joyce Li, Wehong Yang, Xiaochun Yang, Veronica Canadien, Andrei Starostine, Dawn Richards, Bryan Beattie, Nevan Krogan, Michael Davey, John Parkinson, Jack Greenblatt () and Andrew Emili ()
Additional contact information
Gareth Butland: University of Toronto
José Manuel Peregrín-Alvarez: Hospital for Sick Children
Joyce Li: University of Toronto
Wehong Yang: University of Toronto
Xiaochun Yang: University of Toronto
Veronica Canadien: Affinium Pharmaceuticals
Andrei Starostine: University of Toronto
Dawn Richards: Affinium Pharmaceuticals
Bryan Beattie: Affinium Pharmaceuticals
Nevan Krogan: University of Toronto
Michael Davey: University of Toronto
John Parkinson: Hospital for Sick Children
Jack Greenblatt: University of Toronto
Andrew Emili: University of Toronto

Nature, 2005, vol. 433, issue 7025, 531-537

Abstract: Essence of E. coli Proteomic analysis of native protein–protein interactions in E. coli combined with protein mass spectrometry has revealed an interaction network consisting of the proteins essential to bacterial life. The network is highly conserved, providing insight into core bacterial processes, the nature of evolutionary constraints, and suitable new antimicrobial drug targets.

Date: 2005
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DOI: 10.1038/nature03239

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