Is pyrroloquinoline quinone a vitamin?

Robert Rucker (), David Storms, Annemarie Sheets, Eskouhie Tchaparian and Andrea Fascetti
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Robert Rucker: College of Agriculture and Environmental Sciences, University of California
David Storms: College of Agriculture and Environmental Sciences, University of California
Annemarie Sheets: College of Agriculture and Environmental Sciences, University of California
Eskouhie Tchaparian: College of Agriculture and Environmental Sciences, University of California
Andrea Fascetti: School of Veterinary Medicine, University of California

Nature, 2005, vol. 433, issue 7025, E10-E11

Abstract: Abstract Arising from: T. Kasahara & T. Kato Nature 422, 832 (2003); see also communication from Felton and Anthony ; Kasahara et al. reply The announcement by Kasahara and Kato1 of pyrroloquinoline quinone (PQQ) as a ‘new’ vitamin has received considerable attention. We have since attempted to reproduce the findings on which their conclusion is based, namely that defects in lysine metabolism occur in PQQ-deprived rodents. However, we find that the activity of α-aminoadipic acid-δ-semialdehyde (AAS) dehydrogenase in liver and plasma levels of α-aminoadipic acid (AAA), both of which act as indicators of lysine degradation in mammals, are not affected by changes in PQQ dietary status. Our results call into question the identification of PQQ as a new vitamin.

Date: 2005
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DOI: 10.1038/nature03323

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