Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

Karl-Ludwig Laugwitz, Alessandra Moretti, Jason Lam, Peter Gruber, Yinhong Chen, Sarah Woodard, Li-Zhu Lin, Chen-Leng Cai, Min Min Lu, Michael Reth, Oleksandr Platoshyn, Jason X.-J. Yuan, Sylvia Evans () and Kenneth R. Chien ()
Additional contact information
Karl-Ludwig Laugwitz: Institute of Molecular Medicine
Alessandra Moretti: Institute of Molecular Medicine
Jason Lam: Institute of Molecular Medicine
Peter Gruber: Cardiac Center
Yinhong Chen: Institute of Molecular Medicine
Sarah Woodard: Institute of Molecular Medicine
Li-Zhu Lin: Institute of Molecular Medicine
Chen-Leng Cai: Institute of Molecular Medicine
Min Min Lu: University of Pennsylvania
Michael Reth: Universität Freiburg, Biologie III, Abteilung Molekulare Immunologie
Oleksandr Platoshyn: University of California, San Diego, School of Medicine
Jason X.-J. Yuan: University of California, San Diego, School of Medicine
Sylvia Evans: Institute of Molecular Medicine
Kenneth R. Chien: Institute of Molecular Medicine

Nature, 2005, vol. 433, issue 7026, 647-653

Abstract: Stem cell therapy: take heart The field of cardiac stem cell therapy has been something of a minefield. A growth response following the injection of stem cells is notoriously hard to confirm as de novo cardiac myocytes rather than, say, the result of cell fusion. But a paper published this week may move the field on to more solid ground. Laugwitz et al. report the discovery of authentic native cardiac progenitors (cardioblasts) in the postnatal heart, tracking the cells' identity with a marker of a cardiac progenitor field in the embryo (islet-1). The cells were localized in situ in the intact heart, ‘renewed’ by cell culture and purified by a technique based on conditional genetic marking of the lineage: spontaneous differentiation of the cells was clearly documented. These results will raise new hopes that cardiac stem cell therapy will one day become a reality.

Date: 2005
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DOI: 10.1038/nature03215

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