Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Irina M. Conboy, Michael J. Conboy, Amy J. Wagers, Eric R. Girma, Irving L. Weissman and Thomas A. Rando ()
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Irina M. Conboy: Department of Neurology and Neurological Sciences
Michael J. Conboy: Department of Neurology and Neurological Sciences
Amy J. Wagers: Stanford University School of Medicine
Eric R. Girma: Department of Neurology and Neurological Sciences
Irving L. Weissman: Stanford University School of Medicine
Thomas A. Rando: Department of Neurology and Neurological Sciences

Nature, 2005, vol. 433, issue 7027, 760-764

Abstract: The regeneration game Tissues of the body regenerate well in young individuals, less so in older individuals. To find out if this decline is irreversible, or subject to factors in the circulation, Conboy et al. joined together the circulatory systems of young and old mice, as a ‘parabiotic’ pair. Strikingly, regenerative properties of aged muscle and liver were rejuvenated by the serum from younger animals. At the same time there was a restoration of young ‘molecular signatures’, involving Notch signalling (in muscle) and cEBPa-mediated cell cycle regulation (in liver). This suggests that stem and progenitor cells retain proliferative potential even when old, and that the ‘young’ pattern of molecular signalling can reactivate tissue regeneration.

Date: 2005
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DOI: 10.1038/nature03260

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