Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Lee P. Lim (), Nelson C. Lau, Philip Garrett-Engele, Andrew Grimson, Janell M. Schelter, John Castle, David P. Bartel, Peter S. Linsley and Jason M. Johnson
Additional contact information
Lee P. Lim: Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.)
Nelson C. Lau: Massachusetts Institute of Technology
Philip Garrett-Engele: Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.)
Andrew Grimson: Massachusetts Institute of Technology
Janell M. Schelter: Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.)
John Castle: Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.)
David P. Bartel: Massachusetts Institute of Technology
Peter S. Linsley: Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.)
Jason M. Johnson: Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.)

Nature, 2005, vol. 433, issue 7027, 769-773

Abstract: microRNAs edit the message New work on microRNAs (miRNAs) sheds light on the nature of tissue-specific gene expression in humans. miRNAs act in plants and animals to regulate gene expression. Microarray analysis of messenger RNAs expressed in human cells containing miR-124, an miRNA expressed in the brain, or miR-1, found in muscle, shows that the miRNAs skew a cell's expression profile to resemble that of the miRNA's ‘home’ cells, regardless of source. This involves the downregulation of many target mRNA transcripts, as well as reduction of the amount of protein produced.

Date: 2005
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DOI: 10.1038/nature03315

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