DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

Ravi Jagasia, Phillip Grote, Benedikt Westermann and Barbara Conradt ()
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Ravi Jagasia: Max Planck Institute of Neurobiology
Phillip Grote: Dartmouth Medical School
Benedikt Westermann: Universität München
Barbara Conradt: Dartmouth Medical School

Nature, 2005, vol. 433, issue 7027, 754-760

Abstract: Mitochondria: agents of cell death Studies in the nematode Caenorhabditis elegans have been instrumental in the elucidation of the mechanism of apoptosis, the ubiquitous process of programmed cell death required for the elimination of potentially harmful cells. In higher organisms, mitochondria play a crucial role in apoptosis. Now comes evidence that the physical fragmentation of mitochondria is integral to apoptosis in C. elegans too, suggesting that the cell-death activation machinery is universally linked to mitochondria.

Date: 2005
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DOI: 10.1038/nature03316

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