The genome of the protist parasite Entamoeba histolytica

Brendan Loftus (), Iain Anderson, Rob Davies, U. Cecilia M. Alsmark, John Samuelson, Paolo Amedeo, Paola Roncaglia, Matt Berriman, Robert P. Hirt, Barbara J. Mann, Tomo Nozaki, Bernard Suh, Mihai Pop, Michael Duchene, John Ackers, Egbert Tannich, Matthias Leippe, Margit Hofer, Iris Bruchhaus, Ute Willhoeft, Alok Bhattacharya, Tracey Chillingworth, Carol Churcher, Zahra Hance, Barbara Harris, David Harris, Kay Jagels, Sharon Moule, Karen Mungall, Doug Ormond, Rob Squares, Sally Whitehead, Michael A. Quail, Ester Rabbinowitsch, Halina Norbertczak, Claire Price, Zheng Wang, Nancy Guillén, Carol Gilchrist, Suzanne E. Stroup, Sudha Bhattacharya, Anuradha Lohia, Peter G. Foster, Thomas Sicheritz-Ponten, Christian Weber, Upinder Singh, Chandrama Mukherjee, Najib M. El-Sayed, William A. Petri, C. Graham Clark, T. Martin Embley, Bart Barrell, Claire M. Fraser and Neil Hall
Additional contact information
Brendan Loftus: TIGR
Iain Anderson: TIGR
Rob Davies: The Sanger Institute, The Wellcome Trust Genome Campus
U. Cecilia M. Alsmark: School of Biology, University of Newcastle
John Samuelson: Boston University Goldman School of Dental Medicine
Paolo Amedeo: TIGR
Paola Roncaglia: TIGR
Matt Berriman: The Sanger Institute, The Wellcome Trust Genome Campus
Robert P. Hirt: School of Biology, University of Newcastle
Barbara J. Mann: University of Virginia
Tomo Nozaki: National Institute of Infectious Diseases
Bernard Suh: TIGR
Mihai Pop: TIGR
Michael Duchene: Center for Physiology and Pathophysiology, Medical University of Vienna
John Ackers: London School of Hygiene and Tropical Medicine
Egbert Tannich: Bernhard Nocht Institute for Tropical Medicine
Matthias Leippe: University of Kiel
Margit Hofer: Center for Physiology and Pathophysiology, Medical University of Vienna
Iris Bruchhaus: Bernhard Nocht Institute for Tropical Medicine
Ute Willhoeft: Bernhard Nocht Institute for Tropical Medicine
Alok Bhattacharya: Jawaharlal Nehru University
Tracey Chillingworth: The Sanger Institute, The Wellcome Trust Genome Campus
Carol Churcher: The Sanger Institute, The Wellcome Trust Genome Campus
Zahra Hance: The Sanger Institute, The Wellcome Trust Genome Campus
Barbara Harris: The Sanger Institute, The Wellcome Trust Genome Campus
David Harris: The Sanger Institute, The Wellcome Trust Genome Campus
Kay Jagels: The Sanger Institute, The Wellcome Trust Genome Campus
Sharon Moule: The Sanger Institute, The Wellcome Trust Genome Campus
Karen Mungall: The Sanger Institute, The Wellcome Trust Genome Campus
Doug Ormond: The Sanger Institute, The Wellcome Trust Genome Campus
Rob Squares: The Sanger Institute, The Wellcome Trust Genome Campus
Sally Whitehead: The Sanger Institute, The Wellcome Trust Genome Campus
Michael A. Quail: The Sanger Institute, The Wellcome Trust Genome Campus
Ester Rabbinowitsch: The Sanger Institute, The Wellcome Trust Genome Campus
Halina Norbertczak: The Sanger Institute, The Wellcome Trust Genome Campus
Claire Price: The Sanger Institute, The Wellcome Trust Genome Campus
Zheng Wang: TIGR
Nancy Guillén: Institut Pasteur
Carol Gilchrist: University of Virginia
Suzanne E. Stroup: University of Virginia
Sudha Bhattacharya: Jawaharlal Nehru University
Anuradha Lohia: Bose Institute
Peter G. Foster: The Natural History Museum
Thomas Sicheritz-Ponten: Technical University of Denmark
Christian Weber: Institut Pasteur
Upinder Singh: Stanford University School of Medicine
Chandrama Mukherjee: Bose Institute
Najib M. El-Sayed: TIGR
William A. Petri: University of Virginia
C. Graham Clark: London School of Hygiene and Tropical Medicine
T. Martin Embley: School of Biology, University of Newcastle
Bart Barrell: The Sanger Institute, The Wellcome Trust Genome Campus
Claire M. Fraser: TIGR
Neil Hall: The Sanger Institute, The Wellcome Trust Genome Campus

Nature, 2005, vol. 433, issue 7028, 865-868

Abstract: Amoebiasis: a well-tuned genome The genome sequence of the pathogen Entamoeba histolytica is reported this week. E. histolytica causes amoebiasis, the second most deadly protozoan disease after malaria. The genome contains adaptations shared with other anaerobic pathogens such as Trichomonas and Giardia. And there is evidence that the genome has been shaped by many gene transfers from bacteria, which may suggest possible targets for drugs against these organisms. The identification of a large number of sensing and signalling proteins challenges the idea that E. histolytica is a simple organism: in fact it is finely attuned to its environment.

Date: 2005
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DOI: 10.1038/nature03291

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