The MET oncogene drives a genetic programme linking cancer to haemostasis

Carla Boccaccio (), Gabriella Sabatino, Enzo Medico, Flavia Girolami, Antonia Follenzi, Gigliola Reato, Antonino Sottile, Luigi Naldini and Paolo M. Comoglio
Additional contact information
Carla Boccaccio: University of Turin Medical School
Gabriella Sabatino: University of Turin Medical School
Enzo Medico: University of Turin Medical School
Flavia Girolami: University of Turin Medical School
Antonia Follenzi: University of Turin Medical School
Gigliola Reato: University of Turin Medical School
Antonino Sottile: University of Turin Medical School
Luigi Naldini: University of Turin Medical School
Paolo M. Comoglio: University of Turin Medical School

Nature, 2005, vol. 434, issue 7031, 396-400

Abstract: Blood clotting and cancer Since migratory thrombophlebitis was noted by Trousseau during diagnosis of his own pancreatic cancer in 1865, blood clotting disorders have been regularly reported as a sign of occult (as in without readily detectable symptoms) malignancies. No direct link between tumorigenesis and blood clotting had been found, until now. In a mouse model for liver cancer, the human oncogene MET that triggers tumour development is shown to regulate genes responsible for haemostasis. Mice in which MET is active develop venous thromboses similar to those seen in human occult malignancies and overt cancers.

Date: 2005
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DOI: 10.1038/nature03357

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