Leptin regulation of bone resorption by the sympathetic nervous system and CART

Florent Elefteriou, Jong Deok Ahn, Shu Takeda, Michael Starbuck, Xiangli Yang, Xiuyun Liu, Hisataka Kondo, William G. Richards, Tony W. Bannon, Masaki Noda, Karine Clement, Christian Vaisse and Gerard Karsenty ()
Additional contact information
Florent Elefteriou: Department of Molecular and Human Genetics
Jong Deok Ahn: Department of Molecular and Human Genetics
Shu Takeda: Department of Molecular and Human Genetics
Michael Starbuck: Department of Molecular and Human Genetics
Xiangli Yang: Department of Molecular and Human Genetics
Xiuyun Liu: Department of Molecular and Human Genetics
Hisataka Kondo: Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone
William G. Richards: Amgen Inc., Neuroscience
Tony W. Bannon: Amgen Inc., Neuroscience
Masaki Noda: Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone
Karine Clement: INSERM Avenir team–University Paris 6
Christian Vaisse: University of California San Francisco
Gerard Karsenty: Department of Molecular and Human Genetics

Nature, 2005, vol. 434, issue 7032, 514-520

Abstract: Leptin link to osteoporosis Bone structure and function are maintained by bone remodelling, a balance of bone resorption by osteoclasts and bone formation by osteoblasts. New work in mice suggests that leptin, best known as a hormone regulating body weight, may play a major role in striking this balance. In one pathway, leptin stimulation of sympathetic neurons promotes differentiation of osteoclasts (and resorption) and in the other, a neuropeptide called CART inhibits osteoclast differentiation. Blockade of the leptin-regulated neural pathway might help prevent bone loss in osteoporosis.

Date: 2005
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DOI: 10.1038/nature03398

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