Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

Sonya S. Glasson, Roger Askew, Barbara Sheppard, Brenda Carito, Tracey Blanchet, Hak-Ling Ma, Carl R. Flannery, Diane Peluso, Kim Kanki, Zhiyong Yang, Manas K. Majumdar and Elisabeth A. Morris ()
Additional contact information
Sonya S. Glasson: Wyeth Research
Roger Askew: Wyeth Research
Barbara Sheppard: Wyeth Research
Brenda Carito: Wyeth Research
Tracey Blanchet: Wyeth Research
Hak-Ling Ma: Wyeth Research
Carl R. Flannery: Wyeth Research
Diane Peluso: Wyeth Research
Kim Kanki: Wyeth Research
Zhiyong Yang: Wyeth Research
Manas K. Majumdar: Wyeth Research
Elisabeth A. Morris: Wyeth Research

Nature, 2005, vol. 434, issue 7033, 644-648

Abstract: Osteoarthritis: a joint effort The degradation of cartilage in arthritic joints is associated with loss of aggrecan, a large aggregating proteoglycan, and for many years researchers have sought the ‘aggrecanase’ responsible. Two groups now report success: the enzyme ADAMTS5 (also known as aggrecanase-2) is shown to be the primary aggrecanase in the mouse model of osteoarthritis. More work is needed to tie this in with the disease in humans, but the inhibition of ADAMTS5 now becomes a candidate therapeutic for human osteoarthritis.

Date: 2005
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DOI: 10.1038/nature03369

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