ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East, Suzanne B. Golub, Kate E. Lawlor, Clare T. Meeker, Christopher B. Little, Karena Last, Pamela J. Farmer, Ian K. Campbell, Anne M. Fourie and Amanda J. Fosang ()
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Heather Stanton: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital
Fraser M. Rogerson: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital
Charlotte J. East: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital
Suzanne B. Golub: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital
Kate E. Lawlor: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital
Clare T. Meeker: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital
Christopher B. Little: University of Sydney, Royal North Shore Hospital
Karena Last: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital
Pamela J. Farmer: Royal Children's Hospital
Ian K. Campbell: The Walter and Eliza Hall Institute of Medical Research
Anne M. Fourie: Johnson & Johnson Pharmaceutical Research and Development
Amanda J. Fosang: University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital

Nature, 2005, vol. 434, issue 7033, 648-652

Abstract: Osteoarthritis: a joint effort The degradation of cartilage in arthritic joints is associated with loss of aggrecan, a large aggregating proteoglycan, and for many years researchers have sought the ‘aggrecanase’ responsible. Two groups now report success: the enzyme ADAMTS5 (also known as aggrecanase-2) is shown to be the primary aggrecanase in the mouse model of osteoarthritis. More work is needed to tie this in with the disease in humans, but the inhibition of ADAMTS5 now becomes a candidate therapeutic for human osteoarthritis.

Date: 2005
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DOI: 10.1038/nature03417

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