Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice

Sabine Steffens, Niels R. Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Andreas Zimmer, Jean-Louis Frossard and François Mach ()
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Sabine Steffens: University Hospital, Faculty of Medicine
Niels R. Veillard: University Hospital, Faculty of Medicine
Claire Arnaud: University Hospital, Faculty of Medicine
Graziano Pelli: University Hospital, Faculty of Medicine
Fabienne Burger: University Hospital, Faculty of Medicine
Christian Staub: University Hospital, Faculty of Medicine
Andreas Zimmer: University of Bonn
Jean-Louis Frossard: University Hospital, Faculty of Medicine
François Mach: University Hospital, Faculty of Medicine

Nature, 2005, vol. 434, issue 7034, 782-786

Abstract: Cardiovascular action of THC The immunosuppressive and anti-inflammatory effects of cannabinoids are well documented, and pre-clinical studies provide the rationale for their use to treat autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Atherosclerosis is now recognized as a chronic inflammatory disease of the large arteries, so it made sense to test the effects of the cannabinoid THC in a mouse atherosclerosis model. Oral administration of THC does indeed have a beneficial effect on established atherosclerosis in mice, at a surprisingly low dose, suggesting a novel use of this drug in cardiovascular diseases.

Date: 2005
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DOI: 10.1038/nature03389

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