Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor

Yan Li, Yi-Chang Jia, Kai Cui, Ning Li, Zai-Yu Zheng, Yi-zheng Wang () and Xiao-bing Yuan ()
Additional contact information
Yan Li: Chinese Academy of Sciences
Yi-Chang Jia: Chinese Academy of Sciences
Kai Cui: Chinese Academy of Sciences
Ning Li: Chinese Academy of Sciences
Zai-Yu Zheng: Chinese Academy of Sciences
Yi-zheng Wang: Chinese Academy of Sciences
Xiao-bing Yuan: Chinese Academy of Sciences

Nature, 2005, vol. 434, issue 7035, 894-898

Abstract: Axons ‘taste’ their route Two groups this week show that embryonic nerves rely on unexpected sensory devices to guide their growth. The findings help to build a picture of how brains get wired. Ion channels formed by transient receptor potential (TRP) proteins allow adult sensory organs to respond to temperature, mechanical stress or taste. Gordon Wang and Mu-ming Poo have now found TRP channels in an unexpected place: at the tip of embryonic nerves, where the calcium ion currents that they control allow nerves to grow towards or away from guidance molecules. Li et al. show that TRP channels have similar roles in the guidance of growing nerves in the developing cerebellum.

Date: 2005
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DOI: 10.1038/nature03477

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