The genome sequence of the rice blast fungus Magnaporthe grisea

Ralph A. Dean (), Nicholas J. Talbot, Daniel J. Ebbole, Mark L. Farman, Thomas K. Mitchell, Marc J. Orbach, Michael Thon, Resham Kulkarni, Jin-Rong Xu, Huaqin Pan, Nick D. Read, Yong-Hwan Lee, Ignazio Carbone, Doug Brown, Yeon Yee Oh, Nicole Donofrio, Jun Seop Jeong, Darren M. Soanes, Slavica Djonovic, Elena Kolomiets, Cathryn Rehmeyer, Weixi Li, Michael Harding, Soonok Kim, Marc-Henri Lebrun, Heidi Bohnert, Sean Coughlan, Jonathan Butler, Sarah Calvo, Li-Jun Ma, Robert Nicol, Seth Purcell, Chad Nusbaum, James E. Galagan and Bruce W. Birren
Additional contact information
Ralph A. Dean: North Carolina State University
Nicholas J. Talbot: University of Exeter, Washington Singer Laboratories
Daniel J. Ebbole: Texas A&M University
Mark L. Farman: University of Kentucky
Thomas K. Mitchell: North Carolina State University
Marc J. Orbach: University of Arizona
Michael Thon: Texas A&M University
Resham Kulkarni: North Carolina State University
Jin-Rong Xu: Purdue University
Huaqin Pan: North Carolina State University
Nick D. Read: University of Edinburgh
Yong-Hwan Lee: Seoul National University
Ignazio Carbone: North Carolina State University
Doug Brown: North Carolina State University
Yeon Yee Oh: North Carolina State University
Nicole Donofrio: North Carolina State University
Jun Seop Jeong: North Carolina State University
Darren M. Soanes: University of Exeter, Washington Singer Laboratories
Slavica Djonovic: Texas A&M University
Elena Kolomiets: Texas A&M University
Cathryn Rehmeyer: University of Kentucky
Weixi Li: University of Kentucky
Michael Harding: University of Arizona
Soonok Kim: Seoul National University
Marc-Henri Lebrun: Bayer Cropscience
Heidi Bohnert: Bayer Cropscience
Sean Coughlan: Agilent Technologies
Jonathan Butler: Broad Institute of MIT and Harvard
Sarah Calvo: Broad Institute of MIT and Harvard
Li-Jun Ma: Broad Institute of MIT and Harvard
Robert Nicol: Broad Institute of MIT and Harvard
Seth Purcell: Broad Institute of MIT and Harvard
Chad Nusbaum: Broad Institute of MIT and Harvard
James E. Galagan: Broad Institute of MIT and Harvard
Bruce W. Birren: Broad Institute of MIT and Harvard

Nature, 2005, vol. 434, issue 7036, 980-986

Abstract: Abstract Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.

Date: 2005
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DOI: 10.1038/nature03449

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