A synthetic multicellular system for programmed pattern formation

Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold and Ron Weiss ()
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Subhayu Basu: Princeton University
Yoram Gerchman: Princeton University
Cynthia H. Collins: California Institute of Technology 210-41
Frances H. Arnold: California Institute of Technology 210-41
Ron Weiss: Princeton University

Nature, 2005, vol. 434, issue 7037, 1130-1134

Abstract: Pattern formation is in the genes Multicellular organisms, and some single-celled organisms, are capable of producing predetermined patterns. Patterning is key to developmental processes, and is also relevant to tissue engineering and biomaterials design. Basu et al. describe a new synthetic multicellular system in which cells are genetically programmed to form patterns on a surface based on cell–cell communication. Genetic circuits were constructed from well defined simple parts in bacteria that integrate transcriptional regulation with cell–cell signalling elements. These circuits transform a lawn of undifferentiated cells into two-dimensional patterns that resemble a bullseye, ellipse, heart and clover.

Date: 2005
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DOI: 10.1038/nature03461

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