Lipoprotein particles are required for Hedgehog and Wingless signalling

Daniela Panáková, Hein Sprong, Eric Marois, Christoph Thiele () and Suzanne Eaton ()
Additional contact information
Daniela Panáková: Max Planck Institute of Molecular Cell Biology and Genetics
Hein Sprong: Utrecht University
Eric Marois: Max Planck Institute of Molecular Cell Biology and Genetics
Christoph Thiele: Max Planck Institute of Molecular Cell Biology and Genetics
Suzanne Eaton: Max Planck Institute of Molecular Cell Biology and Genetics

Nature, 2005, vol. 435, issue 7038, 58-65

Abstract: Abstract Wnt and Hedgehog family proteins are secreted signalling molecules (morphogens) that act at both long and short range to control growth and patterning during development. Both proteins are covalently modified by lipid, and the mechanism by which such hydrophobic molecules might spread over long distances is unknown. Here we show that Wingless, Hedgehog and glycophosphatidylinositol-linked proteins copurify with lipoprotein particles, and co-localize with them in the developing wing epithelium of Drosophila. In larvae with reduced lipoprotein levels, Hedgehog accumulates near its site of production, and fails to signal over its normal range. Similarly, the range of Wingless signalling is narrowed. We propose a novel function for lipoprotein particles, in which they act as vehicles for the movement of lipid-linked morphogens and glycophosphatidylinositol-linked proteins.

Date: 2005
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature03504 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:435:y:2005:i:7038:d:10.1038_nature03504

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature03504

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().