LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

Xiaoqin Ye, Kotaro Hama, James J. A. Contos, Brigitte Anliker, Asuka Inoue, Michael K. Skinner, Hiroshi Suzuki, Tomokazu Amano, Grace Kennedy, Hiroyuki Arai, Junken Aoki and Jerold Chun ()
Additional contact information
Xiaoqin Ye: The Scripps Research Institute
Kotaro Hama: University of Tokyo
James J. A. Contos: Fred Hutchinson Cancer Research Center
Brigitte Anliker: The Scripps Research Institute
Asuka Inoue: University of Tokyo
Michael K. Skinner: Washington State University
Hiroshi Suzuki: University of Tokyo
Tomokazu Amano: University of Tokyo
Grace Kennedy: The Scripps Research Institute
Hiroyuki Arai: University of Tokyo
Junken Aoki: University of Tokyo
Jerold Chun: The Scripps Research Institute

Nature, 2005, vol. 435, issue 7038, 104-108

Abstract: Embryo implantation The molecular mechanisms affecting female reproduction, particularly therapeutically tractable ones, are incompletely understood. So the identification of a new signalling mechanism affecting fertility via embryo implantation could be important. The compound involved is lysophosphatidic acid (LPA), acting through a G protein-coupled receptor. Targeted deletion of the receptor, called LPA3, produces mice that display delayed implantation, altered implantation spacing, hypertrophic placentas and embryonic death. G protein-coupled receptors are among the most common targets of drug action, raising the possibility of developing new medicines for the treatment of infertility by targeting the LPA3 receptor.

Date: 2005
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DOI: 10.1038/nature03505

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