Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity

Li-Ru You, Fu-Jung Lin, Christopher T. Lee, Francesco J. DeMayo, Ming-Jer Tsai () and Sophia Y. Tsai ()
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Li-Ru You: Department of Molecular and Cellular Biology
Fu-Jung Lin: Department of Molecular and Cellular Biology
Christopher T. Lee: Department of Molecular and Cellular Biology
Francesco J. DeMayo: Department of Molecular and Cellular Biology
Ming-Jer Tsai: Department of Molecular and Cellular Biology
Sophia Y. Tsai: Department of Molecular and Cellular Biology

Nature, 2005, vol. 435, issue 7038, 98-104

Abstract: Blood vessels: changing tubes They may both look like small tubes but arteries and veins are in fact anatomically and functionally distinct. Little is known about how vein identity is established, but studies in mouse embryos now show that the transcription factor COUP-TFII specifically marks the venous endothelium and regulates vein identity, thus challenging the current notion that vein identity results from a default pathway. COUP-TFII, a member of the orphan nuclear receptor superfamily, is expressed at high levels in the endothelium of veins but not in arteries. Selective removal of COUP-TFII in the venous endothelium results in activation of the Notch signalling pathway (an arterial marker) and ectopic induction of haematopoietic cell clusters (an arterial function), thus converting the mutant vein to acquire molecular and functional characteristics of an artery.

Date: 2005
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DOI: 10.1038/nature03511

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