Vascular respiratory uncoupling increases blood pressure and atherosclerosis

Carlos Bernal-Mizrachi, Allison C. Gates, Sherry Weng, Takuji Imamura, Russell H. Knutsen, Pascual DeSantis, Trey Coleman, R. Reid Townsend, Louis J. Muglia and Clay F. Semenkovich ()
Additional contact information
Carlos Bernal-Mizrachi: Metabolism & Lipid Research
Allison C. Gates: Metabolism & Lipid Research
Sherry Weng: Metabolism & Lipid Research
Takuji Imamura: Washington University School of Medicine
Russell H. Knutsen: Washington University School of Medicine
Pascual DeSantis: Metabolism & Lipid Research
Trey Coleman: Metabolism & Lipid Research
R. Reid Townsend: Metabolism & Lipid Research
Louis J. Muglia: Washington University School of Medicine
Clay F. Semenkovich: Metabolism & Lipid Research

Nature, 2005, vol. 435, issue 7041, 502-506

Abstract: Affairs of the blood vessels Coronary heart disease is the most common cause of death in industrialized societies but a clear cause for heart attacks can be identified in only about half of cases. Some of the unexplained cases may be caused by a previously unrecognized mechanism reported this week: inefficient metabolism in the walls of blood vessels. The discovery was made in mice, where respiratory uncoupling in smooth muscle cells, the most common cell type in the artery wall, caused high blood pressure and atherosclerosis. These experimental conditions are like those that result from mitochondrial dysfunction. Pharmacological and nutritional regimes designed to enhance the metabolism in the vasculature may therefore be worth considering as treatments for atherosclerosis.

Date: 2005
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature03527 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:435:y:2005:i:7041:d:10.1038_nature03527

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature03527

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().