SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells

Christopher S. Sullivan, Adam T. Grundhoff, Satvir Tevethia, James M. Pipas and Don Ganem ()
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Christopher S. Sullivan: University of California
Adam T. Grundhoff: University of California
Satvir Tevethia: The Pennsylvania State College of Medicine
James M. Pipas: University of Pittsburgh
Don Ganem: University of California

Nature, 2005, vol. 435, issue 7042, 682-686

Abstract: Viral microRNAs MicroRNAs are a large class of noncoding small RNAs, about 22 nucleotides in length, thought to target other genes and regulate their expression. Their regulatory role has been demonstrated in lower organisms: microRNAs are present in mammals including humans, though their role in higher organisms is not clear. Now they have been found to have a function in virus biology. SV40 virus encodes several microRNAs involved in the late stages of infection of monkey cells. These microRNAs maintain viral replicative efficiency by reducing excess antigen production. It has been suggested that inhibitory RNA systems in mammals are there as a defence against viruses, suggesting that what is normally an antiviral defence pathway is being subverted by the virus for its own purposes.

Date: 2005
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DOI: 10.1038/nature03576

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