Cellular and genetic mechanisms of self tolerance and autoimmunity

Christopher C. Goodnow (), Jonathon Sprent, Barbara Fazekas de St Groth and Carola G. Vinuesa
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Christopher C. Goodnow: John Curtin School of Medical Research
Jonathon Sprent: IMM4, The Scripps Research Institute
Barbara Fazekas de St Groth: Centenary Institute of Cancer Medicine and Cell Biology
Carola G. Vinuesa: John Curtin School of Medical Research

Nature, 2005, vol. 435, issue 7042, 590-597

Abstract: Abstract The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body. Inevitably, some of these receptors recognize components of our own body, and so cellular mechanisms have evolved to control the activity of these ‘forbidden’ receptors and achieve immunological self tolerance. Many of the genes and proteins involved are conserved between humans and other mammals. This provides the bridge between clinical studies and mechanisms defined in experimental animals to understand how sets of gene products coordinate self-tolerance mechanisms and how defects in these controls lead to autoimmune disease.

Date: 2005
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DOI: 10.1038/nature03724

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