Regulation of immunity by self-reactive T cells

Mitchell Kronenberg () and Alexander Rudensky ()
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Mitchell Kronenberg: La Jolla Institute for Allergy and Immunology
Alexander Rudensky: Howard Hughes Medical Institute and Department of Immunology

Nature, 2005, vol. 435, issue 7042, 598-604

Abstract: Abstract A basic principle of immunology is that lymphocytes respond to foreign antigens but tolerate self tissues. For developing T cells, the ability to distinguish self from non-self is acquired in the thymus, where the majority of self-reactive cells are eliminated. Recently, however, it has become apparent that some self-reactive T cells avoid being destroyed and instead differentiate into specialized regulatory cells. This appears to be beneficial. Subpopulations of self-reactive T cells have a strong influence on self tolerance and may represent targets for therapeutic intervention to control a variety of autoimmune diseases, tumour growth and infection.

Date: 2005
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DOI: 10.1038/nature03725

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