c-Myc-regulated microRNAs modulate E2F1 expression

Kathryn A. O'Donnell, Erik A. Wentzel, Karen I. Zeller, Chi V. Dang and Joshua T. Mendell ()
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Kathryn A. O'Donnell: Johns Hopkins University School of Medicine
Erik A. Wentzel: Johns Hopkins University School of Medicine
Karen I. Zeller: Johns Hopkins University School of Medicine
Chi V. Dang: Johns Hopkins University School of Medicine
Joshua T. Mendell: Johns Hopkins University School of Medicine

Nature, 2005, vol. 435, issue 7043, 839-843

Abstract: MicroRNA in cancer MicroRNAs are regulatory, non-coding RNAs about 22 nucleotides in length: over 200 have been identified in humans, and their functions are beginning to be pinned down. It has been suggested that like other regulatory molecules they might be involved in tumour formation, and three papers in this issue confirm that this is the case. One cluster of microRNAs, known as mir-17–92, is shown to be a potential oncogene by its action in an in vivo model of human B-cell lymphoma. A cluster of microRNAs on human chromosome 13 has been found to be regulated by c-Myc, an important transcription factor that is overexpressed in many human cancers. And analysis of microRNA expression in over 300 individuals shows that microRNA profiles could be of value in cancer diagnosis. There is a global downregulation of microRNA in tumours, and the microRNA profile also reflects the origin and differentiation state of the tumours.

Date: 2005
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DOI: 10.1038/nature03677

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