MicroRNA expression profiles classify human cancers

Jun Lu, Gad Getz, Eric A. Miska, Ezequiel Alvarez-Saavedra, Justin Lamb, David Peck, Alejandro Sweet-Cordero, Benjamin L. Ebert, Raymond H. Mak, Adolfo A. Ferrando, James R. Downing, Tyler Jacks, H. Robert Horvitz and Todd R. Golub ()
Additional contact information
Jun Lu: Broad Institute of MIT and Harvard
Gad Getz: Broad Institute of MIT and Harvard
Eric A. Miska: Massachusetts Institute of Technology
Ezequiel Alvarez-Saavedra: Massachusetts Institute of Technology
Justin Lamb: Broad Institute of MIT and Harvard
David Peck: Broad Institute of MIT and Harvard
Alejandro Sweet-Cordero: MIT Center for Cancer Research
Benjamin L. Ebert: Broad Institute of MIT and Harvard
Raymond H. Mak: Broad Institute of MIT and Harvard
Adolfo A. Ferrando: Dana-Farber Cancer Institute and Harvard Medical School
James R. Downing: St. Jude Children's Research Hospital
Tyler Jacks: Massachusetts Institute of Technology
H. Robert Horvitz: Massachusetts Institute of Technology
Todd R. Golub: Broad Institute of MIT and Harvard

Nature, 2005, vol. 435, issue 7043, 834-838

Abstract: MicroRNA in cancer MicroRNAs are regulatory, non-coding RNAs about 22 nucleotides in length: over 200 have been identified in humans, and their functions are beginning to be pinned down. It has been suggested that like other regulatory molecules they might be involved in tumour formation, and three papers in this issue confirm that this is the case. One cluster of microRNAs, known as mir-17–92, is shown to be a potential oncogene by its action in an in vivo model of human B-cell lymphoma. A cluster of microRNAs on human chromosome 13 has been found to be regulated by c-Myc, an important transcription factor that is overexpressed in many human cancers. And analysis of microRNA expression in over 300 individuals shows that microRNA profiles could be of value in cancer diagnosis. There is a global downregulation of microRNA in tumours, and the microRNA profile also reflects the origin and differentiation state of the tumours.

Date: 2005
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DOI: 10.1038/nature03702

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